If the left portal vein is affected by a tumor, which functional lobe is primarily affected?

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The left portal vein supplies the left functional liver lobe. When a tumor obstructs or invades this vein, the left lobe receives reduced blood flow and is the part of the liver most directly affected. The caudate lobe (segment I) gets blood from both left and right portal veins and drains directly into the IVC, so it is not primarily driven by the left portal vein. The right lobe is fed by the right portal vein, so it would be affected by pathology on that side. Therefore, the left lobe is the primary region impacted when the left portal vein is involved.