What does the liver manufacture that is released into the blood?

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The key idea is that the liver makes substances that circulate in the blood, especially plasma proteins. Hepatocytes synthesize proteins like albumin and various clotting factors, and these are released directly into the bloodstream to perform important functions such as maintaining blood oncotic pressure and supporting coagulation.

Hormones are typically produced by endocrine glands, not the liver’s main output. Urea is produced in the liver as a nitrogen waste product and enters the blood for excretion by the kidneys, but it isn’t a functional protein carrying out blood-borne tasks. Platelets are produced in the bone marrow from megakaryocytes, not manufactured by the liver.