Where are albumin and globulins synthesized?

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The liver is the primary site for making most plasma proteins, including albumin and many globulins. Albumin is produced by hepatocytes in the liver and is essential for keeping plasma oncotic pressure and for carrying numerous substances. Globulins encompass several groups, and many alpha and beta globulins (such as transferrin, ceruloplasmin, and various transport and coagulation factors) are also synthesized by the liver. Note that immunoglobulins (gamma globulins) are produced mainly by plasma cells in bone marrow and lymphoid tissue, not in the liver, but the liver still makes the major portion of the non-immunoglobulin globulins. The kidneys, pancreas, and spleen do not serve as the primary sources for producing these plasma proteins.