Which condition is associated with increased ALP due to bone turnover?

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Alkaline phosphatase has two main tissue sources: bone and liver. When bone turnover increases, osteoblasts ramp up production of alkaline phosphatase to support mineralization and remodeling, so the serum level goes up due to the bone-specific isoenzyme. This rise is seen in conditions with high bone formation or repair, such as bone diseases or rapid bone growth in children, where osteoblastic activity is elevated. Hepatitis raises alkaline phosphatase primarily from the liver isoenzyme, usually in the setting of cholestasis or other liver injury, not from bone turnover. Dehydration and pulmonary embolism do not directly cause a rise in bone-derived alkaline phosphatase. So the association with increased ALP due to bone turnover is bone disease.