Which of the following statements about serum protein composition is true?

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Serum protein composition is dominated by albumin and globulins; after blood clots, the fluid left behind (serum) lacks fibrinogen and other clotting factors, so those proteins aren’t counted in serum. Albumin is the most abundant serum protein, contributing about 60% of total serum protein. Globulins account for roughly 35–40%, and together these two groups make up well over half of the total serum protein. That’s why the statement is true: albumin plus globulins comprise more than half of total serum protein. Fibrinogen and prothrombin are clotting factors found in plasma, not serum, while transferrin is only a relatively minor component; immunoglobulins are a major type of globulins but do not constitute the entire globulin portion.