Which substance are albumin and globulins primarily responsible for transporting?

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The main idea here is that plasma needs carrier proteins to handle molecules that don’t dissolve well in water. Albumin is the most abundant plasma protein and binds a wide range of hydrophobic compounds—long-chain fatty acids, bilirubin, many drugs, and similar nonpolar substances—to keep them soluble and transport them to tissues or the liver for processing. Globulins include transporters such as transferrin for iron and ceruloplasmin for copper, as well as other carriers that bind lipids and fat-soluble components. Together, albumin and these globulins specialize in moving substances that are insoluble in water, which is why they are described as primarily responsible for transporting water-insoluble substances. Water-soluble vitamins are typically carried dissolved in plasma or by specific carriers; gases are mainly carried by hemoglobin or dissolved, and while some hormones use binding proteins, the broad, defining role of these proteins is to shuttle insoluble substances.